Jozsef Nagy, Julia Maier, Wolfgang Fenz, Zoltan Major, Andreas Gruber, Matthias Gmeiner

Abstract: We analyzed the growth process of a single cerebral aneurysm using Fluid-Structure Interaction (FSI) simulations establishing a history including important events in morphology, hemodynamics as well as structural mechanics. Data of one patient was obtained between the years 2012 and 2022. The medical imaging data of these aneurysms was provided in the form of digital subtraction angiography, which was transformed into stereolithography format as geometry input. With the FSI simulations typical hemodynamic (wall shear stress, oscillatory shear index) and a structural mechanic quantity (Mises stress) were identified. With the addition of morphological parameters (Size, Volume, L2-norm of Gaussian curvature) significant changes can be found during the growth history of the selected aneurysm. Wall shear stress is highest during aneurysm initiation, while decreasing during aneurysm growth. Oscillatory shear index increases over time especially in the region of strong aneurysm growth. Strong changes in geometry induce subsequent changes in hemodynamics. Wall stress remains constant throughout the growth period of the selected aneurysm. However, shortly before aneurysm rupture wall stress increases significantly.

Keywords: cerebral aneurysms, growth history, Fluid-Structure Interaction, aneurysm initiation, aneurysm rupture

Date Published: September 25, 2024
DOI: 10.11159/jbeb.2024.002

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