Mina Gayed, Dina M. Gaber, Nabila Borae

Abstract: To investigate the influence of the physical state and composition of lipid materials on the preparation performance of lipid nanocarriers, two types of carriers were prepared and compared: solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs). To assess the ability of these nanocarriers to promote effective drug delivery of drug to liver for management of liver cancer, Fenretinide (FEN) was employed as a model drug. The FEN encapsulation efficiency in these NLCS was greater than 97% compared to 93% for SLNs. Further loading capacity increased 2 folds in case of NLCs. Furthermore, the unchanged size and size distribution of these nanoparticles for 3 months at room temperature demonstrated their stability in such conditions. However, MTT experiments proved that FEN-SLNs are more effective for delivering FEN to HepG2 cells than NLCs with 3 folds enhancement in cytotoxic activity. Therefore, this study showed that by optimally controlling the lipid physical state and composition, it is possible to fabricate the solid lipid nanoparticles with desired properties.

Keywords: Liver cancer, lipid based nanocarriers, loading efficiency.

Date Published: September 29, 2023
DOI: 10.11159/ijtan.2023.001

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